Follow the Given Steps.

1. Install latest version of EmSignor from GST website and Prefer Internet Explorer 9 or above. 
2. Add https://127.0.0.1:portNo (port on which Emsigner is running on) and 
https://www.gst.gov.in/ to Java ( Control Panel > java > Security TAB>Edit site list) and
Internet Explorer ( Internet Explorer > ☼ > Internet Option > Security TAB > Trusted Sites > Sites )
3. Rum Emsigner and Internet Explorer As Administrator.
4. Use https://www.gst.gov.in/ in Internet Explorer. 

We are good to go